0468 Effects of apnea-induced SWS disruption with and without supplemental oxygen on overnight spatial memory in CPAP-treated OSA

Abstract Introduction Sleep disturbance from obstructive sleep apnea (OSA) impairs overnight memory processing. This may be mediated by changes to slow wave (SWS) as less activity (SWA) is associated with worse spatial and declarative memory. We developed a within-subjects model of SWS-specific CPAP-withdrawal create 3 polysomnologically (PSG)-verified conditions 1) stable-SWS on CPAP, 2) SWS-fragmentation intermittent hypoxemia (OSAsws), 3) reduced (OSAsws+O2). Using these conditions, we sought dissociate effects SWS disruption navigational Methods included 33 patients (7 female, average age 54yrs) moderate-to-severe OSA (AHI4%>20/hr) who were CPAP-treatment adherent. During each PSG visit, they explored one three 3D maze environments, performing timed trials before after randomized counterbalanced [1)CPAP, 2)OSASWS & 3)OSASWS+O2]. %SWS, severity during SWS, frontal SWA(0.5-4 Hz), change in completion times compared according condition using Friedman Rank Sum Conover’s tests. The relationship between SWA performance was tested Pearson correlation coefficient. Results %SWS significantly greater CPAP (CPAP=17.2%, OSAsws=13.3%, OSAsws+O2=13.8%, p< 0.02). Apnea hypopnea index (AHI3A) (CPAP=0/hr, OSAsws=24.4/hr, OSAsws+O2=19.3/hr, 0.00001). Hypoxic burden the OSAsws+O2 vs OSAsws (23 %min/hr 37 %min/hr, p < 0.001). No significant differences observed for or times. When including all visits, better improvements (R=0.28,p< 0.01) which approached significance isolation (R=0.33,p=0.068). Conclusion resulted recurrence mild SWS; supplemental oxygen hypoxic burden, but did not differ without. There was, however, an overall positive performance. These observations suggest that effect navigation hypoxia SWA. Support (if any) R01AG056682, AASM Focused Project Award.